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A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.
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A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
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The method of claim 1 wherein said method is a wet grinding process. 6. The method of claim 1 wherein said method is a dry grinding process. ... While this invention is described herein in connection with its preferred utilities, i.e., with respect to drug substances for use in pharmaceutical compositions and imaging agents for use in x-ray ...
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Sep 01, 2010 Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavy
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Finest wet grinding technology – the laboratory mills of the MicroSeries are an investment in the future for new product developments of different fields of application of pigmented ink jets, technical ceramics, cosmetics, pharmaceutical applications and nano-scale high-tech products.
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Continuous method of grinding pharmaceutical substances Download PDF Info Publication number EP0804161B1. EP0804161B1 EP19950919062 EP95919062A EP0804161B1 EP 0804161 B1 EP0804161 B1 EP 0804161B1 EP 19950919062 EP19950919062 EP 19950919062 EP 95919062 A EP95919062 A EP 95919062A EP 0804161 B1 EP0804161 B1 EP 0804161B1
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Wet milling is a scalable method applicable to drugs with different physicochemical and mechanical properties. Nanocrystalline-based formulations, either as liquid nanosuspensions or after downstream processing to solid dosage forms, have been developed as drug delivery systems for various routes of administration (i.e., oral, parenteral ...
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The particles are prepared by dispersing a drug substance or imaging agent in a liquid dispersion medium and wet grinding in the presence of rigid grinding media. Liversidge et al do not suggest a continuous milling process wherein the grinding media is separated from the pharmaceutical agent outside the milling chamber.
Read MoreA continuous method of preparing submicron particles of a therapeutic or diagnostic agent comprises the steps of continuously introducing the agent and rigid grinding media into a milling chamber, contacting the agent with the grinding media while in the chamber to reduce the particle size of the agent, continuously removing the agent and the grinding media from the milling chamber, and ...
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Mar 01, 2018 Milling has a long history as a unit operation in pharmaceutical technology, but it is the advent of new devices with increased rotational speed and finer milling media that allows the use of milling as a nanonization technique. Currently, wet milling is the method behind most of the marketed nanocrystalline-based products.
Read MoreSep 01, 2010 Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavy
Read MoreWet milling is a scalable method applicable to drugs with different physicochemical and mechanical properties. Nanocrystalline-based formulations, either as liquid nanosuspensions or after downstream processing to solid dosage forms, have been developed as drug delivery systems for various routes of administration (i.e., oral, parenteral ...
Read More
Rotor–stator wet mills are commonly used in the pharmaceutical industry to reduce particle size and normalize API physical properties as a means to facilitate downstream drug product operations and/or achieve targeted in vivo product performance. Wet milling is robust, relatively easy to use, broadly applicable, and offers both financial and API physical property advantages over dry milling ...
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A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
Read More
Wet granulation method of tablet production involves the following processing steps: Step 1: Weighing and mixing of formulation ingredients (excluding the lubricant). This step involves the weighing, sifting and introduction of specified quantities of drug substance
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A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin.
Read More
The method enables the use of fine grinding media, e.g., of a particle size of less than about 300 'mu'm, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the ...
Read MoreMar 01, 2018 Milling has a long history as a unit operation in pharmaceutical technology, but it is the advent of new devices with increased rotational speed and finer milling media that allows the use of milling as a nanonization technique. Currently, wet milling is the method behind most of the marketed nanocrystalline-based products.
Read More
Wet milling with IKA's inline machines is a safe and efficient alternative to dry grinding. Dry grinding creates a lot of dust which causes the need for proper filtering systems. This can be of particular importance during grinding of substances whose dust, when mixed with aerial oxygen, can result in explosive mixtures.
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Wet chemistry is a form of analytical chemistry that uses classical methods such as observation to analyze materials. It is called wet chemistry since most analyzing is done in the liquid phase. Wet chemistry is also called bench chemistry since many tests
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Pharma Cosmetics Pharma Cosmetics Dispersing Homogenizing Wet Grinding De-Aerating Laboratory Machines NETZSCH-Beads ® Laboratory Tests Seminars Webinars Biotechnology Cosmetics / Personal Hygiene Pharmaceuticals *NEW* NETZSCH Notify – NETZSCH Machine Monitoring in Real Time Extremely small batches for Active Pharmaceutical Substances ...
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Wet media milling is an established technique for the commercialized top-down production of nanoparticulate drug suspensions. These drug nanosuspensions can be transferred into the related drug products, like capsules, tablets and injectables. The generation of wear during stirred media milling of a
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At these settings, predicted values of grinding capacity, grinding recovery, and APD are 142.3 kg h-1, 100% and 0.494 mm, respectively. End-user requirements for fine grinding and good machine ...
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of poorly soluble substances from given pharmaceutical . ... by melting method) of the substance in poloxamer 188 ... was obtained by wet grinding of the crystalline tranilast .
Read MoreSep 01, 2010 Dry grinding of organic substances requires elaborate exhaust and filter fans that are meant to avert the danger of dust explosions. Wet grinding processes offer an efficient alternative and are able to achieve even very small particle sizes. Heavy
Read MoreRotor–stator wet mills are commonly used in the pharmaceutical industry to reduce particle size and normalize API physical properties as a means to facilitate downstream drug product operations and/or achieve targeted in vivo product performance. Wet milling is robust, relatively easy to use, broadly applicable, and offers both financial and API physical property advantages over dry milling ...
Read MoreWet granulation method of tablet production involves the following processing steps: Step 1: Weighing and mixing of formulation ingredients (excluding the lubricant). This step involves the weighing, sifting and introduction of specified quantities of drug substance
Read MoreA method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.
Read MoreA method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin.
Read More
METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES (PAT - EP0760653) CZEKAI David A., SEAMAN Larry P. NanoSystems L.L.C. Patent: Publ. of Application with search report - European Patent Office. Application: EP19950919828 on 1995-05-12 Publication: 1997-03-12. Abstract: Highlight Terms ...
Read MoreThe method enables the use of fine grinding media, e.g., of a particle size of less than about 300 'mu'm, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the ...
Read MoreWet milling with IKA's inline machines is a safe and efficient alternative to dry grinding. Dry grinding creates a lot of dust which causes the need for proper filtering systems. This can be of particular importance during grinding of substances whose dust, when mixed with aerial oxygen, can result in explosive mixtures.
Read MoreMar 01, 2018 Milling has a long history as a unit operation in pharmaceutical technology, but it is the advent of new devices with increased rotational speed and finer milling media that allows the use of milling as a nanonization technique. Currently, wet milling is the method behind most of the marketed nanocrystalline-based products.
Read MoreWet chemistry is a form of analytical chemistry that uses classical methods such as observation to analyze materials. It is called wet chemistry since most analyzing is done in the liquid phase. Wet chemistry is also called bench chemistry since many tests
Read Moreof poorly soluble substances from given pharmaceutical . ... by melting method) of the substance in poloxamer 188 ... was obtained by wet grinding of the crystalline tranilast .
Read More
Products Wet Grinding Dry Grinding Mixing / De-Aerating Dispersing Homogenizing Classifying ... NETZSCH Machine Monitoring in Real Time Extremely small batches for Active Pharmaceutical Substances ... microbiology and process engineering is used to produce specific substances with new production methods, for example, in bioreactors with the ...
Read MoreAt these settings, predicted values of grinding capacity, grinding recovery, and APD are 142.3 kg h-1, 100% and 0.494 mm, respectively. End-user requirements for fine grinding and good machine ...
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Wet Granulation • In the pharmaceutical industry, granulation refers to the act or process in which primary powder particles are made to adhere to form larger, multiparticle entities called granules. • It is the process of collecting particles together by creating bonds
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