- صفحة رئيسية
- من نحن
- المنتجات
- مركز الحالات
- اتصل بنا
-
الخط الساخن
0371-86549132
الخط الساخن
Benign lymphoid aggregates are seen in only a minority of bone marrow specimens, but their distinction from non-Hodgkin lymphoma, particularly B-cell lymphomas, can represent a diagnostic challenge. Although criteria have been proposed to help distinguish between benign and malignant aggregates, a d
Read More
We have developed the B cell-dependent MP4-induced experimental autoimmune encephalomyelitis (EAE) as a mouse model to mimic this trait of the human disease. The aim of this study was to determine a potential role of lymphoid tissue inducer (LTi) and T H 17 cells in the process of B cell aggregate formation in the MP4 model.
Read More
Apr 01, 2013 1. Introduction. Lymphoid aggregates, whether benign or malignant, are a relatively uncommon finding in bone marrow biopsy specimens. In many cases, identifying the neoplastic nature of the aggregates by morphology can be easily achieved; however, in instances when multiple aggregates are identified with no documented history of lymphoma, such distinction may be difficult to achieve
Read More
Organized lymphoid aggregates are normally found within the walls of bronchi in many species and may occur, under conditions of disease, in humans. This bronchus-associated lymphoid tissue (BALT) can be viewed as an organizing principle to explain the behavior and distribution of many pulmonary lymp
Read More
Lymphoid aggregates in children were larger, with follicles, but less numerous and tended to be located in the intermediate and deeper parts of the gastric mucosa. Immunohistochemical studies showed an increase of IgA, IgM and lymphocytes T in the deeper part of the lamina propria in H. pylori-associated gastritis and lymphocyte T accumulation ...
Read More
Aug 01, 2019 See also persistent polyclonal lymphocytosis, plasmacytosis, polymorphous reactive lymphoid hyperplasia and systemic polyclonal B immunoblastic proliferation; Lymphoid aggregates, whether benign or malignant, are relatively uncommon in bone marrow (BM) biopsy specimens Distinguishing benign and malignant (i.e. lymphoma) aggregates can be challenging, especially when multiple aggregates
Read More
BACKGROUND AND AIMS A histopathological feature considered indicative of ulcerative colitis (UC) is the so-called basal lymphoid aggregates. Their relevance in the pathogenesis of UC is, however, unknown. We have performed a comprehensive analysis of the immune cells in these aggregates most likely corresponding to the lymphoid
Read More
Gut-associated lymphoid tissue (GALT) is a component of the mucosa-associated lymphoid tissue (MALT) which works in the immune system to protect the body from invasion in the gut.. Owing to its physiological function in food absorption, the mucosal
Read More
Lymphoid proliferations are traditionally thought to be either benign conditions (reactive hyperplasia and lymphadenitis) or malignant lymphomas. However, not all lymphoid lesions at present can be precisely placed into one of these categories. Therefore, in addition to these two extremes, there als
Read More
Jan 01, 2012 This chapter discusses the hematopoietic and lymphoid tissues. The lymph nodes are peripheral organs that house a major subset of mature lymphoid cells. The lymph nodes serve a similar function in the mouse and human and are critical in mediating immune reactions to exogenous and endogenous stimuli.
Read More
Processing of Bronchial Biopsies. ... Previous observations of lymphoid aggregates in human airways were made in studies of lung tissue obtained either at surgery or at post mortem. The aggregates in our study have similarities as well as differences to BALT as described in animal and human lung tissue (1, 2, 11, 12). The similarities are ...
Read More
This is the typical appearance of a benign lymphoid aggregate in bone marrow; it is nodular, nonparatrabecular, well circumscribed, and composed of predominantly small mature lymphocytes. Typical immunohistochemical findings in a benign lymphoid aggregate
Read More
Structure. The gut-associated lymphoid tissue lies throughout the intestine, covering an area of approximately 260–300 m 2. In order to increase the surface area for absorption, the intestinal mucosa is made up of finger-like projections (), covered by a monolayer
Read More
Aim: To investigate the development of lymphoid aggregates in the conjunctiva after corneal transplantation in rats. Methods: LEW or PVG strain corneas were transplanted orthotopically to PVG rats. Cornea and conjunctiva were examined clinically for up to 42 days. Eyes were removed with attached conjunctiva on days 10 and 15 after transplantation (before and during rejection), together
Read MoreJan 01, 2012 This chapter discusses the hematopoietic and lymphoid tissues. The lymph nodes are peripheral organs that house a major subset of mature lymphoid cells. The lymph nodes serve a similar function in the mouse and human and are critical in mediating immune reactions to exogenous and endogenous stimuli.
Read More
The molecular and cellular processes driving the formation of secondary lymphoid tissues have been extensively studied using a combination of mouse knockouts, lineage-specific reporter mice, gene expression analysis, immunohistochemistry, and flow cytometry. However, the mechanisms driving the formation and function of tertiary lymphoid
Read More
May 28, 2019 We have developed the B cell-dependent MP4-induced experimental autoimmune encephalomyelitis (EAE) as a mouse model to mimic this trait of the human disease. The aim of this study was to determine a potential role of lymphoid tissue inducer (LTi) and TH17 cells in the process of B cell aggregate
Read More
3 Lymphoid tissue in the gut comprises the following: • Tonsils (Waldeyer's ring) • Adenoids (Pharyngeal tonsils) • Peyer's patches – lymphoid follicles in wall of small intestine • Lymphoid aggregates in the appendix and large intestine • Lymphoid tissue accumulating with age in the stomach • Small lymphoid aggregates in the esophagus • Diffusely distributed lymphoid cells and ...
Read More
Cell Aggregates. PBMC aggregates are shown to replicate many of the histological and molecular features of human granulomatous diseases, such as tuberculosis, leprosy, schistosomiasis, and sarcoidosis.23–26 These models are unique in that they provide access to early, dynamic granuloma formation mechanisms, which are not evident from single-cell experiments or diseased tissue samples.
Read More
In this article we will discuss about the primary and secondary lymphoid organs of immune system. Primary or Central Lymphoid Organs:. Immature lymphocytes generated in hematopoiesis, the process of formation and development of blood cells, mature and become committed to a particular antigenic specificity within the primary lymphoid organs, namely, thymus, bursa of Fabricius (in birds) and ...
Read More
Lymphoid Organogenesis. Lymphoid organogenesis is a complex process characterized by sequential events, including: (i) early interaction between lymphoid tissue inducers (lymphotoxin α1β2) and stromal organizer cells (lymphotoxin-β-receptor), (ii) development of high endothelial venules (HEVs) and homing of circulating lymphocytes, and (iii) B- and T-cell compartimentalization.
Read More
Lymphoid aggregates (LA) develop during the proliferative phase of the menstrual cycle in the human uterine endometrium (EM). They contain mostly CD8+ T cells and B cells. As these LA are absent immediately following menses, they may arise by division of cells resident in the EM, or by division of a
Read More
processing of human lymphoid aggregates. Processing of Bronchial Biopsies. Previous observations of lymphoid aggregates in human airways were made in studies of lung tissue obtained either at surgery or at post mortem. The aggregates in our study have similarities as well as differences to BALT as described in animal and human
Read More
Unique CD8 T cell-rich lymphoid aggregates in human uterine endometrium Grant R. Yeaman,* Paul M. Guyre,t Michael W. Fanger,* Jane E. Collins,* Hillary D. White,* Wayne Rathbun Kenneth A. Orndorff,t Jorge Gonzalez,t Judy E. Stern, and Charles R. Wirat *Depajrtment of Microbiology, t Physiology, 1 Pathology, and § Obstetrics Gynecology, Dartmouth Medical School, Lebanon, New Hampshire ...
Read MoreLymphoid Organogenesis. Lymphoid organogenesis is a complex process characterized by sequential events, including: (i) early interaction between lymphoid tissue inducers (lymphotoxin α1β2) and stromal organizer cells (lymphotoxin-β-receptor), (ii) development of high endothelial venules (HEVs) and homing of circulating lymphocytes, and (iii) B- and T-cell compartimentalization.
Read More
Jun 20, 2014 can exist as simple lymphoid aggregates or as more sophis - ticated structures that histologically resemble secondary lymphoid organs (SLOs)7,8 (TABLE 1). The spatial organiza-tion of leukocytes into defined, compartmentalized B cell-rich and T cell-rich zones is termed lymphoid
Read MoreThe molecular and cellular processes driving the formation of secondary lymphoid tissues have been extensively studied using a combination of mouse knockouts, lineage-specific reporter mice, gene expression analysis, immunohistochemistry, and flow cytometry. However, the mechanisms driving the formation and function of tertiary lymphoid
Read More
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS and prolonged patient’s survival in more than 10 different types of cancer.
Read MoreCell Aggregates. PBMC aggregates are shown to replicate many of the histological and molecular features of human granulomatous diseases, such as tuberculosis, leprosy, schistosomiasis, and sarcoidosis.23–26 These models are unique in that they provide access to early, dynamic granuloma formation mechanisms, which are not evident from single-cell experiments or diseased tissue samples.
Read More3 Lymphoid tissue in the gut comprises the following: • Tonsils (Waldeyer's ring) • Adenoids (Pharyngeal tonsils) • Peyer's patches – lymphoid follicles in wall of small intestine • Lymphoid aggregates in the appendix and large intestine • Lymphoid tissue accumulating with age in the stomach • Small lymphoid aggregates in the esophagus • Diffusely distributed lymphoid cells and ...
Read MoreIn this article we will discuss about the primary and secondary lymphoid organs of immune system. Primary or Central Lymphoid Organs:. Immature lymphocytes generated in hematopoiesis, the process of formation and development of blood cells, mature and become committed to a particular antigenic specificity within the primary lymphoid organs, namely, thymus, bursa of Fabricius (in birds) and ...
Read MoreAug 22, 2019 The Crohn's-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC. CLR is characterized by peritumoral lymphocytic aggregates that
Read Moreprocessing of human lymphoid aggregates. Processing of Bronchial Biopsies. Previous observations of lymphoid aggregates in human airways were made in studies of lung tissue obtained either at surgery or at post mortem. The aggregates in our study have similarities as well as differences to BALT as described in animal and human
Read More
B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph. At the SLO, B cell activation begins when the B cell
Read More
The bronchus-associated lymphoid tissue (BALT) and the nasal-associated lymphoid tissue (NALT) constitute organized lymphoid aggregates that are capable of T- and B-cell responses to inhaled antigens.
Read More
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed tissues. Secondary lymphoid organs develop as a part of a genetically preprogrammed process
Read More
Jun 06, 2019 Further supporting the identification of the mixed lymphoid aggregates in the CP of MRL/lpr as TLSs are our recent studies of the T cell population . We found that a subset of CP-infiltrating CD4 + T cells in MRL/lpr mice displayed a Tfh-like phenotype, as evidenced by their surface markers and IL-21 expression.
Read More
